Clinica Mediterranea, Naples, Italy. Institute of Cardiology and Center of Excellence on Aging, "G. d'Annunzio" University - Chieti, C/o Ospedale SS. Annunziata, Via dei Vestini, 66013, Chieti, Italy. Department of Cardiothoracic Sciences, Monaldi Hospital, Second University of Naples, Naples, Italy. Department of Molecular Medicine and Medical Biotechnologies, "Federico II" University of Naples, Naples, Italy. Dimensione Ricerca, Milan, Italy. ES Health Science Foundation, Lugo, Italy. Institute of Cardiology and Center of Excellence on Aging, "G. d'Annunzio" University - Chieti, C/o Ospedale SS. Annunziata, Via dei Vestini, 66013, Chieti, Italy. rdecater@unich.it.